Sarecycline free base

CAS No. 1035654-66-0

Sarecycline free base( —— )

Catalog No. M23244 CAS No. 1035654-66-0

Sarecycline free base is a tetracycline-derived, narrow-spectrum antibiotic.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1G 4928 In Stock

Biological Information

  • Product Name
    Sarecycline free base
  • Note
    Research use only, not for human use.
  • Brief Description
    Sarecycline free base is a tetracycline-derived, narrow-spectrum antibiotic.
  • Description
    Sarecycline free base is a tetracycline-derived, narrow-spectrum antibiotic.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Carrageenan-induced footpad edema male Sprague Dawley rats modelDosage:1 mg/kg, 5 mg/kg ,10 mg/kg, 25 mg/kg, 50 mg/kg, 75 mg/kg,100 mg/kg, 150 mg/kg Administration:Intraperitoneal injection (i.p.); Single dose. Before a subplantar injection of sterile 1 mg/0.1 mL carrageenan solution in the right hind paw.Result:Reduced inflammation to 55.7% and 53.1%, respectively, at doses of 75 mg/kg and 100 mg/kg compared to baseline.Animal Model:Carrageenan-induced footpad edema male Sprague Dawley rats model Dosage:0.33, 1, 3, or 9?mg/kg Administration:Intravenously Result:Achieved a 2-log10 reduction in the bacterial burden in the thigh at a dose comparable to that of doxycycline, with ED50s of 8.23 and 8.32?mg/kg, respectively.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1035654-66-0
  • Formula Weight
    487.5
  • Molecular Formula
    C24H29N3O8
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (205.13 mM)
  • SMILES
    CN(C)[C@@H]([C@H](C[C@H](Cc1c(CNCOC)ccc(O)c1C1=O)C1=C1O)[C@]11O)C(O)=C(C(N)=O)C1=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Pinazo A , Manresa M A , Marques A M , et al. Amino acid–based surfactants: New antimicrobial agents[J]. Advances in Colloid and Interface Science, 2016, 228:17-39.
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